Radical-Mediated α-<i>tert</i>-Alkylation of Aldehydes by Consecutive 1,4- and 1,3-(Benzo)thiazolyl Migrations
Jige Liu, Jiangshan Ma, Tongkun Wang, Xiao‐Song Xue, Chen Zhu
Abstract
High Resolution Image Download MS PowerPoint Slide The direct alkylation of the α-position of aldehydes is an effective method for accessing a wide range of structurally diverse aldehydes, yet tert -alkylation has proven to be a challenging task. In this study, we present a novel radical-mediated tert -alkylation approach targeting the α-position of aldehydes, enabling the synthesis of complex aliphatic aldehydes. The transformation is initiated by the interaction between an in situ generated enamine intermediate and α-bromo sulfone, forming an electron donor–acceptor (EDA) complex, followed by consecutive 1,4- and 1,3-functional group migrations. This protocol operates under metal-free and mild photochemical conditions, delivering a broad scope of products and providing new mechanistic insights into radical rearrangement reactions.