Temperate Bacteriophages—The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions
Martyna Cieślik, Natalia Bagińska, Ewa Jończyk‐Matysiak, Alicja Węgrzyn, Grzegorz Węgrzyn, Andrzej Górski
Abstract
Bacteriophages are natural biological entities that limit the growth and amplification of bacteria. They are important stimulators of evolutionary variability in bacteria, and currently are considered a weapon against antibiotic resistance of bacteria. Nevertheless, apart from their antibacterial activity, phages may act as modulators of mammalian immune responses. In this paper, we focus on temperate phages able to execute the lysogenic development, which may shape animal or human immune response by influencing various processes, including phagocytosis of bacterial invaders and immune modulation of mammalian host cells.
Topics & Concepts
Immune systemBacteriaBiologyLysogenic cycleMicrobiologyPhagocytosisBacteriophageImmunologyGeneticsEscherichia coliGeneBacteriophages and microbial interactionsViral gastroenteritis research and epidemiologyAquaculture disease management and microbiota