Electrochemically-driven difunctionalization of the isocyanide and Mumm rearrangement cascade: expeditious synthesis of <i>N</i>-acyl–<i>N</i>-alkyl <i>S</i>-thiocarbamates
Kuldeep Singh Bhati, Siddharth Sharma
Abstract
-thiocarbamate derivatives that are found in several biologically active compounds. The effectiveness of the μ-electro flow reactor (μ-EFR) was showcased through significant reduction in electrolyte volume during the reaction, achieving gram-scale production of 4a within a short 12 min residence time using a Pt/Pt flow cell.
Topics & Concepts
ThiocarbamatesIsocyanideThiocarbamateChemistryAlkylCombinatorial chemistryThioetherOrganic chemistryMedicinal chemistrySulfur-Based Synthesis TechniquesMulticomponent Synthesis of HeterocyclesRadical Photochemical Reactions