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Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance

Zhengye Liu, Zheng Yang, Mourboul Ablise

2024Bioorganic Chemistry14 citationsDOI

Topics & Concepts

HeLaCisplatinChemistryChalconeTubulinCancer cellMicrotubule polymerizationMicrotubuleCancer researchCellBiochemistryCell biologyCancerStereochemistryBiologyChemotherapyGeneticsToxin Mechanisms and ImmunotoxinsFungal Plant Pathogen Control14-3-3 protein interactions
Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance | Litcius