Amide N–C Bond Activation: A Graphical Overview of Acyl and Decarbonylative Coupling
Chengwei Liu, Michal Szostak
Abstract
This Graphical Review provides an overview of amide bond activation achieved by selective oxidative addition of the N-C(O) acyl bond to transition metals and nucleophilic acyl addition, resulting in acyl and decarbonylative coupling together with key mechanistic details pertaining to amide bond distortion underlying this reactivity manifold.
Topics & Concepts
AmideReactivity (psychology)Peptide bondChemistryDecarbonylationNucleophileCoupling (piping)BondStereochemistryOrganic chemistryMaterials scienceCatalysisEnzymePathologyFinanceMetallurgyMedicineEconomicsAlternative medicineAdvanced Synthetic Organic ChemistryChemical Synthesis and AnalysisChemical synthesis and alkaloids