Discovery of tert-amine-based RORγt agonists
Ruomeng Qiu, Mingcheng Yu, Juwen Gong, Jinlong Tian, Yafei Huang, Yonghui Wang, Qiong Xie
Topics & Concepts
Orphan receptorRAR-related orphan receptor gammaChemistryAgonistNuclear receptorRetinoic acidCD8T cellReceptorTranscription factorImmunotherapyStereochemistryCancer researchPharmacologyBiochemistryCancerImmune systemInternal medicineImmunologyBiologyMedicineGeneIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionPsoriasis: Treatment and Pathogenesis