Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors
Dongqian Huang, Wenye Li, Yilan Zhao, Cheng Xie, Xiaogang Luo, Fengshou Wu, Zhi‐Qiang Xu, Qi Sun, Genyan Liu
Topics & Concepts
ChemistryIsoxazoleXanthine oxidaseCarboxylic acidChemical synthesisStereochemistryEnzyme inhibitorCombinatorial chemistryEnzymeBiochemistryIn vitroGout, Hyperuricemia, Uric AcidBiochemical and Molecular ResearchPharmacological Effects of Natural Compounds