Ruthenium(<scp>ii</scp>)-catalyzed reductive N–O bond cleavage of<i>N</i>-OR (R = H, alkyl, or acyl) substituted amides and sulfonamides
Tingjie You, Maosheng Zhang, Jianhui Chen, Hongmei Liu, Yuanzhi Xia
Abstract
A convenient method for the reductive cleavage of the N–O bonds of amide derivatives was developed using ruthenium(<sc>ii</sc>)-catalyzed transfer hydrogenation reaction.
Topics & Concepts
ChemistryRutheniumCatalysisCleavage (geology)AmideAlkylMedicinal chemistryBond cleavageTransfer hydrogenationReductive eliminationStereochemistryOrganic chemistryGeotechnical engineeringEngineeringFracture (geology)Asymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic Chemistry