Innervation of adipocytes is limited in mouse perivascular adipose tissue
Marie Hanscom, Wilmarie Morales‐Soto, Stephanie W. Watts, William F. Jackson, Brian D. Gulbransen
Abstract
This study challenges prevailing views on neural innervation in perivascular adipose tissue (PVAT) and its role in adrenergic-driven anticontractile effects on vasculature. Contrary to existing paradigms, limited anatomical and functional connections were found between PVAT nerve fibers and adipocytes, underscoring the importance of exploring alternative mechanistic pathways. Understanding the mechanisms involved in PVAT's anticontractile effects is critical for developing potential therapeutic interventions against dysregulated vascular tone, hypertension, and cardiovascular disease.
Topics & Concepts
Adipose tissuePerivascular spacePathologyBiologyAnatomyInternal medicineEndocrinologyMedicineCardiovascular Disease and AdiposityAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases