The N-heterocyclic carbene-catalyzed [3 + 2] annulation of isoindigos with enals: the enantioselective construction of three contiguous stereogenic centers
Binghao Liu, Jing Qi, Yatong Wu, Jiahui Li, Yanting Li, Xiaoyong Duan
Abstract
An NHC-catalyzed enantioselective [3 + 2] annulation of enals and isoindigo is introduced as an efficient strategy for the construction of dimeric spirocyclic bisindoline alkaloid derivatives with moderate yields and good enantioselectivities.
Topics & Concepts
StereocenterEnantioselective synthesisAnnulationChemistryCarbeneCatalysisAlkaloidStereochemistryOrganocatalysisOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods