ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
Xueqiang Deng, Xuan Yi, Da Huang, Peng Liu, Leifeng Chen, Yunyan Du, Liang Hao
Abstract
and triggered apoptotic osteosarcoma cell death. ROCK2 inhibited the TRAIL-mediated apoptotic pathway in osteosarcoma cells and promoted activation. Mechanistically, ROCK2 affected osteosarcoma progression and TRAIL resistance by modifying O-GlcNAcylation through O-GlcNAc transferase degradation. Taken together, our results demonstrated a unique mechanism whereby ROCK2 influences osteosarcoma progression and TRAIL resistance, hence improving osteosarcoma management.
Topics & Concepts
OsteosarcomaCancer researchRHOAFlow cytometryApoptosisROCK2Gene silencingChemistryBiologyMolecular biologySignal transductionCell biologyBiochemistryGeneGlycosylation and Glycoproteins ResearchCancer-related Molecular PathwaysBiochemical and Molecular Research