The <i>Drosophila</i> spectraplakin Short stop regulates focal adhesion dynamics by cross-linking microtubules and actin
Andrew J. Zhao, Julia Montes-Laing, Wick M.G. Perry, Mari Shiratori, Emily Merfeld, Stephen L. Rogers, Derek A. Applewhite
Abstract
border cells as an in vivo model for cell migration, we found that RNAi depletion led to precocious border cell migration. Collectively, these results suggest that spectraplakins not only function to cross-link the cytoskeleton but may regulate cell-matrix adhesion.
Topics & Concepts
Focal adhesionCell biologyCell migrationBiologyCytoskeletonMicrotubuleAdhesionCell adhesionActinActin cytoskeletonDynamics (music)RNA interferenceCellLive cell imagingIn vivoMotilityCellular modelRNACell adhesion moleculeNeuronal migrationPTK2Skin and Cellular Biology ResearchCellular Mechanics and InteractionsCell Adhesion Molecules Research