Site-Selective Functionalization of C(sp³) Vicinal Boronic Esters

Abstract

Selective functionalization of the C−B bond in 1,2-
\nbis(boronate) esters has emerged as a powerful tool to prepare 1,2-
\ndifunctionalized compounds with stereocontrol. Selective Suzuki crosscoupling, oxidation, amination, and homologation reactions serve as
\nplatforms to prepare a wide variety of compounds from a common
\nintermediate. The exquisite selectivity offered and their easy preparation
\nfrom feedstock material using a myriad of catalytic transformations
\nmake them attractive building blocks for the preparation of complex molecules. In this Perspective, we summarize the examples of
\nselective C−B bond functionalization of vicinal bis(boronates), attending to the nature of the C−B bond functionalization

Topics & Concepts