Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions
Tiantian Chen, Hai‐Jian Yang, Yang Yang, Guangbin Dong, Dong Xing
Abstract
We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.
Topics & Concepts
CatalysisRedoxChemistryNickelAlkylationRegioselectivity1,3-ButadieneCopperCombinatorial chemistryInorganic chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and Catalysis