Therapeutic potential of 1,3,4-oxadiazoles as potential lead compounds for the treatment of Alzheimer's disease
Saira Naseem, Ahmed Temirak, Aqeel Imran, Saquib Jalil, Shamool Fatima, Parham Taslımı, Jamshed Iqbal, Mussarat Tasleem, Muhammad Nawaz Tahir, Zahid Shafiq
Abstract
of 0.11 μM and high selectivity (∼25-fold) over MAO-B and AChE enzymes. These newly synthesized analogues represent promising hits for the development of promising lead compounds for neurological disease treatment.
Topics & Concepts
DiseaseLead (geology)ChemistryPharmacologyMedicineBiologyInternal medicinePaleontologyCholinesterase and Neurodegenerative DiseasesSynthesis and biological activityComputational Drug Discovery Methods