Yak milk protects against alcohol-induced liver injury in rats
Man Wang, Yanshi Jiang, Siying Wang, Lin Fu, zujin Liang, Ying Zhang, Xiaodan Huang, Xin Li, Meiying Feng, Danfeng Long
Abstract
with ALT and AST levels, while showing a negative correlation with ADH levels. Furthermore, differential metabolite analysis of fecal samples from the YM group identified significant increases in the taurine (2-Aminoethanesulfonic acid), hypotaurine (2-Aminoethanesulfonic Acid) and isethionic acid levels. Finally, KEGG topology analysis highlighted taurine and hypotaurine metabolism as the primary pathways influenced by YM intervention. Therefore, these findings collectively suggest that YM may protect alcohol-exposed rats against liver injury by modulating oxidative stress, inflammatory response, gut microbiota disorder, and metabolic regulation.