Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis
Donghak Kim, Vitchan Kim, Kevin D. McCarty, F. Peter Guengerich
Abstract
complex that also binds POR to form a catalytically competent ternary complex, and variants that disrupt this interaction have low catalytic activity.
Topics & Concepts
Cytochrome b5StimulationSteroidCytochrome P450ChemistryAndrogenCytochromeAndrogen receptorBiochemistryBiologyEnzymeEndocrinologyGeneticsProstate cancerHormoneCancerPharmacogenetics and Drug MetabolismProstate Cancer Treatment and ResearchDrug Transport and Resistance Mechanisms