Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses
Kaiwen Meng, Lijie Zhang, Xiaoyin Xue, Qinghong Xue, Miao Sun, Geng Meng
Abstract
Picornaviridae is a group of RNA viruses that harm both humans and livestock. 3C pro is an essential enzyme for picornavirus maturation, which makes it a promising target for antiviral drug development and a critical component for virus-like particle (VLP) production. However, the current challenge in the development of antiviral drugs and VLP vaccines includes the limited knowledge of how subsite structure determines the 3C pro cleavage pattern.
Topics & Concepts
BiologyProteaseCleavage (geology)VirologyGeneticsMolecular biologyEnzymeBiochemistryFracture (geology)PaleontologyViral Infections and Immunology ResearchAnimal Disease Management and EpidemiologyViral Infections and Vectors