Design and synthesis of hederagenin derivatives modulating STING/NF-κB signaling for the relief of acute liver injury in septic mice
Tao Yu, Haoran Cheng, Xiaoli Li, Wentao Huang, Haixia Li, Xiaojin Gao, Jianing Zhao, Xin Zhang, Xiaoxiao Gu, Yi Bi, Leiming Zhang
Topics & Concepts
StingIn vivoPharmacologySepsisChemistryInflammationLipopolysaccharideNF-κBIκBαIn vitroSignal transductionImmunologyMedicineBiochemistryBiologyEngineeringBiotechnologyAerospace engineeringinterferon and immune responsesImmune Response and InflammationInflammasome and immune disorders