Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [ <sup>11</sup> C]PBR28 in Elderly Individuals Without Dementia
Sini Toppala, Laura L. Ekblad, Jouni Tuisku, Semi Helin, Jarkko Johansson, Hanna Laine, Eliisa Löyttyniemi, Päivi Marjamäki, Kaj Blennow, Henrik Zetterberg, Antti Jula, Matti Viitanen, Juha O. Rinne
Abstract
OBJECTIVE: To examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. METHODS: , total tau, phospho-tau, soluble TREM2, and YKL-40 levels were measured. RESULTS: C]PBR28 binding in brain regions where Aβ accumulation is first detected in Alzheimer disease. CONCLUSIONS: While there was no association between amyloid and neuroinflammation in the overall study group, neuroinflammation was associated with amyloid among the subgroup at early stages of amyloid pathology.