Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization
Chih‐Yuan Ko, Yen‐You Lin, David Achudhan, Jun‐Way Chang, Shan‐Chi Liu, Chao-Yang Lai, Yuan‐Li Huang, Chun‐Hao Tsai, Yi‐Chin Fong, Hsien-Te Chen, Kun‐Tsan Lee, Chien‐Chung Huang, Ting‐Kuo Chang, Chih‐Hsin Tang
Abstract
. Our findings indicate omentin-1 as a promising therapeutic avenue for the treatment for OA.
Topics & Concepts
OsteoarthritisMacrophage polarizationMedicineCytokineMacrophageAdipokineAMPKCartilageInflammationPI3K/AKT/mTOR pathwayIn vivoProinflammatory cytokineInternal medicineImmunologyCancer researchEndocrinologySignal transductionLeptinPathologyBiologyCell biologyPhosphorylationObesityIn vitroAnatomyAlternative medicineBiochemistryProtein kinase ABiotechnologyOsteoarthritis Treatment and MechanismsAdipokines, Inflammation, and Metabolic DiseasesChemokine receptors and signaling