The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji‐Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Abstract
value of ∼250 nM against SFTSV and HRTV in plaque assays. Together, our data support sNSV endonucleases as an antiviral target.
Topics & Concepts
EndonucleaseVirologyVirusEnzymePolymeraseBiologyVirus classificationMolecular biologyGenomeGeneticsGeneBiochemistryViral Infections and VectorsMosquito-borne diseases and controlViral Infections and Outbreaks Research