Alkaline-Metal-Promoted Divergent Synthesis of 1-Aminoisoquinolines and Isoquinolines
Peng Ma, Yuhang Wang, Ning Ma, Jianhui Wang
Abstract
Alkaline-metal-promoted divergent syntheses of 1-aminoisoquinolines and isoquinolines have been reported involving 2-methylaryl aldehydes, nitriles, and LiN(SiMe 3 ) 2 as reactants. In addition, the three-component reaction of 2-methylaryl nitriles, aldehydes, and LiN(SiMe 3 ) 2 has been developed to furnish 1-aminoisoquinolines. This protocol features readily available starting materials, excellent chemoselectivity, broad substrate scope, and satisfactory yields.
Topics & Concepts
ChemoselectivityChemistrySubstrate (aquarium)Scope (computer science)Combinatorial chemistryMetalOrganic chemistryComponent (thermodynamics)CatalysisComputer scienceProgramming languageOceanographyPhysicsGeologyThermodynamicsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloidsAsymmetric Hydrogenation and Catalysis