Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity
Zhen Xiao, Jiajia Wang, Shidian He, Lin Wang, Jingxing Yang, Wen Hui Li, Kaili Ma, Yabo Zhou, Xiaowei Liu, Shiyou Wang, Yang Yu, Minmin Ge, Ang Gao, Kun Tang, Jing Huang, Chen Wang, Liyuan Zhang, Hai-Xi Sun, Lianjun Zhang
Abstract
stem-like T cells. Importantly, FX-engineered T cells trigger robust antigen spreading and potent endogenous polyclonal T cell response, enabling the recognition and elimination of tumors with heterogeneous antigens and preventing immune escape. The therapeutic efficacy of FX-armed chimeric antigen receptor (CAR)-T cells is further validated in the Flt3KO&hFLT3LG humanized mouse model. This strategy offers a promising avenue for enhancing DC-T cell interactions, paving the way for more effective immunotherapy against solid tumors.