Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore
David Anderson Brumley, Sarath P. Gunasekera, Qi-Yin Chen, Valerie J. Paul, Hendrik Luesch
Abstract
New modified depsipeptides and geometric isomers, termed anaenamides A (1a) and B (1b), along with the presumptive biosynthetic intermediate, anaenoic acid (2), were discovered from a marine cyanobacterium from Guam. Structures were confirmed by total synthesis. The alkylsalicylic acid fragment and the C-terminal α-chlorinated α,β-unsaturated ester are novelties in cyanobacterial natural products. Cancer cell viability assays indicated that the C-terminal unit serves as the pharmacophore and that the double-bond geometry impacts the cytotoxicity.
Topics & Concepts
PharmacophoreDepsipeptideChemistryCytotoxicityStereochemistryCancer cell linesPolyketideCombinatorial chemistryTotal synthesisCancer cellBiochemistryCancerIn vitroBiosynthesisGeneBiologyGeneticsMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisChemical Synthesis and Analysis