New imidazo[2,1-<i>b</i>]thiazole-based aryl hydrazones: unravelling their synthesis and antiproliferative and apoptosis-inducing potential
Mohd Adil Shareef, G. Parimala Devi, Sunitha Rani Routhu, C. Ganesh Kumar, Ähmed Kamal, Bathini Nagendra Babu
Abstract
Herein, we have designed and synthesized new imidazo[2,1-<italic>b</italic>]thiazole-based aryl hydrazones (<bold>9a–w</bold>) and evaluated their anti-proliferative potential against a panel of human cancer cell lines.
Topics & Concepts
ThiazoleApoptosisArylStereochemistryChemistryCancer cell linesCombinatorial chemistryCancer cellCancerBiologyBiochemistryGeneticsOrganic chemistryAlkylSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications