Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota
Huiying Fu, Xia Liu, Lu Jin, Jiali Lang, Zhiming Hu, Wen Mao, Changpei Cheng, Qiyang Shou
Abstract
macrophages to improve the immune microenvironment by affecting the expression of collagen fibers. Further cellular experiments showed that SY degraded the collagens in the liver cells through the TGF-β/Smad signalling pathway. SY also regulated the gut microbiota which may contribute to the immune microenvironment. In conclusion, SY exhibited a potent effect on the development of HCC by enhancing liver immune infiltration by promoting collagen degradation and modulating the gut microbiota. This study provides novel insights into the mechanism of SY as a candidate for the treatment of HCC in the future.
Topics & Concepts
Immune systemHepatocellular carcinomaGut floraCancer researchLipopolysaccharideFlow cytometryHepatic stellate cellCD8CarthamusImmunologyBiologyChemistryMedicineTraditional medicineEndocrinologyLiver Disease Diagnosis and TreatmentSunflower and Safflower CultivationHepatocellular Carcinoma Treatment and Prognosis