Small molecule–PNA oligomer conjugates for rRNA A-site at neutral pH for FID assays
En Ting Tabitha Lee, Yusuke Sato, Seiichi Nishizawa
Abstract
= 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays.
Topics & Concepts
OligomerConjugateChemistrySelectivityMoleculeBinding siteSmall moleculeRibosomal RNACombinatorial chemistryStereochemistryBiochemistryOrganic chemistryCatalysisMathematical analysisMathematicsGeneRNA and protein synthesis mechanismsRNA modifications and cancerAdvanced biosensing and bioanalysis techniques