Synergistic Inhibitory Effect of Polymyxin B in Combination with Ceftazidime against Robust Biofilm Formed by Acinetobacter baumannii with Genetic Deficiency in AbaI/AbaR Quorum Sensing
Yinyue Li, Bo Wang, Feng Lü, Juhee Ahn, Wenwen Zhang, Liangliang Cai, Jiahui Xu, Yi Yin, Qingchao Cao, Zhenyu Ren, Xinlong He
Abstract
Deeper explorations of molecular correlation among antibiotic resistance, biofilm formation, and pathogenicity could provide novel insights that would facilitate the development of therapeutics and prevention against A. baumannii biofilm-related infections. The major finding that polymyxin B in combination with ceftazidime displayed a synergistic antibiofilm effect against robust biofilm formed by an A. baumannii strain with genetic deficiency in AbaI/AbaR quorum sensing further provides a theoretical basis for clinical applications of antibiotics in combination with quorum quenching in antibiofilm therapy.
Topics & Concepts
Acinetobacter baumanniiQuorum sensingBiofilmMicrobiologyEffluxPolymyxinBiologyAutoinducerCeftazidimePolymyxin BAntibiotic resistanceAntibioticsGeneticsBacteriaPseudomonas aeruginosaAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntibiotics Pharmacokinetics and Efficacy