Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
Alexander Sandvoß, Johannes M. Wahl
Abstract
Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.
Topics & Concepts
Enantioselective synthesisDesymmetrizationContext (archaeology)ChemistryOrganic chemistryCombinatorial chemistryCatalysisBiologyPaleontologySynthesis and Catalytic ReactionsAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods