Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats
Jia Liu, Kevin W. Aylor, Weidong Chai, Eugene J. Barrett, Zhenqi Liu
Abstract
Muscle microvascular insulin action contributes to insulin-mediated glucose use. Microvascular insulin resistance is an early event in diet-induced obesity and is associated with vascular inflammation. Metformin effectively reduces endothelial oxidative stress, improves endothelial function, and prevents microvascular insulin resistance during obesity development. These may contribute to metformin's salutary diabetes prevention and cardiovascular protective actions.
Topics & Concepts
MetforminInsulin resistanceInternal medicineOxidative stressMedicineEndocrinologyInsulinDiabetes mellitusObesityInflammationEndotheliumEndothelial dysfunctionMetabolism, Diabetes, and CancerAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases