Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice
Fan‐Feng Chen, Jiayu Zhan, Abdullah Al Mamun, Yibing Tao, Shanshan Huang, Jiaxin Zhao, Yu Zhang, Yitie Xu, Shenghu Du, Wei Lü, Xiaokun Li, Zimiao Chen, Jian Xiao
Abstract
Mechanism by which SFN improving microvascular damage in limbs insulted by I/R injury. SFN activates TFEB via MCOLN1-calcineurin signaling. SFN-induced TFEB activation augments autophagy restoration, anti-oxidant response and anti-apoptosis effect.
Topics & Concepts
SulforaphaneIschemiaReperfusion injuryPharmacologyMedicineChemistryCell biologyBiologyCardiologyBiochemistryGenomics, phytochemicals, and oxidative stressAutophagy in Disease and TherapyAdenosine and Purinergic Signaling