Lignans from <i>Lepidium meyenii</i> and Their Anti‐Inflammatory Activities
Yi‐Yan Zou, Dawei Wang, Yong‐Ming Yan, Yong‐Xian Cheng
Abstract
Meyeniines A-C (1-3), three new lignans, two known neolignans (4-5), and three known lignans (6-8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4-6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL-6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.
Topics & Concepts
LignanChemistryRhizomeEnantiomerChiral column chromatographyStereochemistrySesaminLipopolysaccharideAnti-inflammatoryTraditional medicinePharmacologyFood scienceBiologyMedicineEndocrinologyPhytochemistry and Biological ActivitiesNatural product bioactivities and synthesisPlant-derived Lignans Synthesis and Bioactivity