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Mitochondrial damage activates the NLRP10 inflammasome

Tomasz Próchnicki, Matilde B. Vasconcelos, Kim S. Robinson, Matthew Mangan, Dennis M. de Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser Duthie, Maximilian Rothe, Kateryna Antonova, Lea‐Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A. Kufer, Florian I. Schmidt, Franklin L. Zhong, Eicke Latz

2023Nature Immunology78 citationsDOI

Topics & Concepts

InflammasomeAIM2Cell biologyMitochondrionPyroptosisNLRC4BiologyMitochondrial DNAPyrin domainCytosolCaspase 1Signal transducing adaptor proteinProgrammed cell deathInflammationApoptosisSignal transductionImmunologyBiochemistryGeneEnzymeInflammasome and immune disordersErythrocyte Function and Pathophysiologyinterferon and immune responses
Mitochondrial damage activates the NLRP10 inflammasome | Litcius