Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT
Yanyan Zhao, Jing Jia, Jingjing Zhang, Yanping Xun, Shujun Xie, Jiafeng Liang, Honggang Guo, Jiazhen Zhu, Shenglin Ma, Shirong Zhang
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BCancer researchMAPK/ERK pathwayMetastasisCell growthDownregulation and upregulationA549 cellLung cancerMedicineChemistrySignal transductionCancerBiologyInternal medicineCell biologyBiochemistryGeneMast cells and histaminePI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and Applications