Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway
Xincong Li, Yue Zhao, Haoran Peng, Deao Gu, Chao Liu, Shuangshuang Ren, Leiying Miao
Abstract
Graphical Abstract We introduce novel mitophagy enhancer, MitoQ@PssL NPs exert excellently anti-inflammatory effects by activating mitophagy and clearing partial mitochondrial ROS, thereby accelarating osteogenesis in periodontitis.
Topics & Concepts
ParkinOxidative stressPINK1PeriodontitisChemistryMedicineCell biologyBiologyInternal medicineParkinson's diseaseDiseaseAdenosine and Purinergic SignalingAutophagy in Disease and TherapyNeonatal Health and Biochemistry