Decacationic Pillar[5]arene: A New Scaffold for the Development of <sup>129</sup>Xe MRI Imaging Agents
P. U. Ashvin Iresh Fernando, Yurii Shepelytskyi, Paul T. Cesana, Alanna Wade, Vira Grynko, Adriana M. Mendieta, Lauren E. Seveney, Joseph D. Brown, Francis Hane, Mitchell S. Albert, Brenton DeBoef
Abstract
A decacationic water-soluble pillar[5]arene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 103 M–1. These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging.
Topics & Concepts
XenonPillarSupramolecular chemistryChemistryFluorescenceNuclear magnetic resonanceScaffoldMagnetic resonance imagingScaffold proteinBiophysicsCrystallographyOrganic chemistryBiochemistryBiomedical engineeringPhysicsOpticsCrystal structureEngineeringStructural engineeringMedicineRadiologySignal transductionBiologyAtomic and Subatomic Physics ResearchAdvanced NMR Techniques and ApplicationsSupramolecular Chemistry and Complexes