The role(s) of NF-Y in development and differentiation
Diletta Dolfini, Carol Imbriano, Roberto Mantovani
Abstract
NF-Y is a conserved sequence-specific trimeric Transcription Factor -TF- binding to the CCAAT element. We review here the role(s) in development, from pre-implantation embryo to terminally differentiated tissues, by rationalizing and commenting on genetic, genomic, epigenetic and biochemical studies. This effort brings to light the impact of NF-YA isoforms on stemness and differentiation, as well as binding to distal vs promoter proximal sites and connections with selected TFs.
Topics & Concepts
Transcription factorEpigeneticsGene isoformBiologyPromoterCellular differentiationCell biologyGeneticsComputational biologyGeneGene expressionSignaling Pathways in DiseaseNF-κB Signaling PathwaysUbiquitin and proteasome pathways