Minimal information for reporting a genomics experiment
Kostiantyn Dreval, Paul C. Boutros, Ryan D. Morin
Abstract
Exome and genome sequencing has facilitated the identification of hundreds of genes and other regions that are recurrently mutated in hematologic neoplasms. The data sets from these studies theoretically provide opportunities. Quality differences between data sets can confound secondary analyses. We explore the consequences of these on the conclusions from some recent studies of B-cell lymphomas. We highlight the need for a minimum reporting standard to increase transparency in genomic research.
Topics & Concepts
ExomeGenomicsExome sequencingBiologyComputational biologyIdentification (biology)GenomeData qualityGeneticsBioinformaticsGeneMutationEconomicsBotanyOperations managementMetric (unit)Cancer Genomics and DiagnosticsLymphoma Diagnosis and TreatmentSingle-cell and spatial transcriptomics