Absolute coronary flow and microvascular resistance before and after transcatheter aortic valve implantation
Emanuele Gallinoro, Pasquale Paolisso, Dario Tino Bertolone, Giuseppe Esposito, Marta Belmonte, Attilio Leone, Michele Mattia Viscusi, Monika Shumkova, Cristina De Colle, Ivan Degrieck, Filip Casselman, Martin Pěnička, Carlos Collet, Jeroen Sonck, Eric Wyffels, Jozef Bartunek, Bernard De Bruyne, Marc Vanderheyden, Emanuele Barbato
Abstract
BACKGROUND: Severe aortic stenosis (AS) is associated with left ventricular (LV) remodelling, likely causing alterations in coronary blood flow and microvascular resistance. AIMS: We aimed to evaluate changes in absolute coronary flow and microvascular resistance in patients with AS undergoing transcatheter aortic valve implantation (TAVI). METHODS: ) was calculated by dividing absolute flow by the subtended myocardial mass. RESULTS: : 0.34 [IQR 0.30-0.48] vs 0.47 [IQR 0.36-0.67] mL/min/g; p=0.06). CONCLUSIONS: Immediately after TAVI, no changes occurred in absolute coronary flow or coronary flow reserve. Over time, the remodelling of the left ventricle is associated with increased hyperaemic perfusion.