Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome
Han Sun, Yu Zhang, Jiahui Wang, Jun‐Cheng Su, Dejian Zhou, Xiang Yu, Yingjie Xu, Wen Yang
Abstract
This study demonstrates the feasibility of utilizing stable and reliable mRNA to express the immunosuppressive molecule sPD-L1 specifically in the lungs. The findings provide proof of concept for localized nanoparticle delivery and offer a novel therapeutic strategy for treating acute inflammation in ARDS.
Topics & Concepts
ARDSMedicinePulmonary edemaLungInflammationImmune systemMessenger RNAImmunologyPharmacologyChemistryInternal medicineBiochemistryGeneRNA Interference and Gene DeliveryImmune Response and InflammationInhalation and Respiratory Drug Delivery