Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection
Katy M. Alden, Andrew J. Jezewski, Sarah R. Beattie, David Fox, Damian J. Krysan
Abstract
were not viable. These data clearly show that C. neoformans employs multiple carbon metabolism pathways to adapt to the host environment. They also provide insights into the potential mechanism of action for anti-cryptococcal Acs inhibitors.
Topics & Concepts
Cryptococcus neoformansCryptococcosisCryptococcusComputational biologyBiologyMicrobiologyFungal Infections and StudiesAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases