An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics
Shaobo Wang, Qiong Zhang, Hui Hui, Kriti Agrawal, Maile Karris, Tariq M. Rana
Abstract
population to T cell exhaustion and providing an immunotherapy target to treat HIV chronic infection. These data provide a comprehensive analysis of gene signatures associated with immune cell exhaustion during HIV infection, which could be useful in understanding exhaustion mechanisms and developing new cure therapies.
Topics & Concepts
TIGITImmune systemBiologyImmunologyPopulationCD8Peripheral blood mononuclear cellT cellCytotoxic T cellCellVirologyMedicineIn vitroGeneticsBiochemistryEnvironmental healthImmune Cell Function and InteractionT-cell and B-cell ImmunologyHIV Research and Treatment