Visible-Light-Promoted Copper-Catalyzed Etherification of Aryl Bromides via Energy Transfer
Xiantong Yao, Rui-yuan Peng, Xin Yang, Jinheng Zheng, Weijun Zhong, Qinghua Zhong, Zhengjie Wang, Dali Yang, Ruihua Cheng, Yueyue Ma, Jinxing Ye
Abstract
A visible-light-promoted copper-catalyzed C-O coupling reaction of alcohols with aryl bromides using eosin Y as the photosensitizer has been developed, in which energy transfer (EnT) from eosin Y to the copper complex of the oxalamide ligand generates an excited-state copper complex that facilitates oxidative addition of aryl bromides. This mild method enables the efficient synthesis of alkyl aryl ethers and biaryl ethers with a broad substrate scope and excellent tolerance of sensitive functional groups at room temperature.
Topics & Concepts
ChemistryArylCopperEosin YCatalysisEosinPhotochemistryPhotosensitizerVisible spectrumAlkylSubstrate (aquarium)Ligand (biochemistry)Combinatorial chemistryExcited stateOrganic chemistryPhotocatalysisReceptorStainingGeologyMedicineOptoelectronicsPhysicsBiochemistryNuclear physicsPathologyOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques