Finite element analysis of the human mandible: a systematic review with meta-analysis of the essential input parameters
Omid Daqiq, Barzi Gareb, Fred K. L. Spijkervet, Friederik Wilhelm Wubs, Charlotte Christina Roossien, Baucke van Minnen
Abstract
Human mandibular finite element analysis (FEA) requires essential parameters for proper simulation, namely: the forces, fixtures, material properties, and the boundary conditions. The purpose of this systematic review is to determine the evidence-based values of these input parameters. A systematic search strategy was formulated with the search conducted in PUBMED and EMBASE (PROSPERO: CRD42022315303). Only the values from in vivo physical testing were included. Risk of bias was assessed using validated checklists. After screening 13,023 records, 66 records were included; where only the maximum bite force (MBF) (n = 60), muscle force (n = 5), and mandible material properties (n = 5) were found and assessed. Meta-analysis could be only applied for the MBF studies. MBF in the healthy dentulous populations varies, with male and adults (20-60 years) illustrating higher force. A fracture results in MBF reduction, with force increase in postoperative follow-ups. Further, MBF remains higher in partial versus complete denture wearers. In conclusion, the systematic review gives a comprehensive overview of MBF, muscle force, and mandible material properties that can be applied as guideline for defining mandibular FEA input parameters. Further, future in vivo studies are required to uncover the unknown parameters (e.g., friction) and to better specify the known parameters (e.g., muscle force).Systematic Reveiw Registeration: A protocol for this systematic review was specified in advance and published on 7 April 2022 in the PROSPERO (registration number CRD42022315303) (www.crd.york.ac.uk/PROSPERO).