A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes
Anne Talkington, Morgan D. McSweeney, Timothy Wessler, Marielle Rath, Zibo Li, Tao Zhang, Hong Yuan, Jonathan E. Frank, M. Gregory Forest, Yanguang Cao, Samuel K. Lai
Topics & Concepts
BiodistributionPharmacokineticsPEGylationPhysiologically based pharmacokinetic modellingPharmacologyChemistryPEG ratioLiposomeDrugAntibodyMedicineImmunologyPolyethylene glycolBiochemistryIn vitroFinanceEconomicsMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityNanoparticle-Based Drug Delivery