Genetic polymorphisms related to the vitamin D pathway in patients with cirrhosis with or without hepatocellular carcinoma (HCC)
Beatriz de Jesus Brait, Simone Perpétua da Silva Lima, Franciana Luísa Aguiar, Rafael Fernandes-Ferreira, Camila Ive Ferreira Oliveira-Brancati, Joyce Aparecida Martins Lopes Ferraz, Graciela Domitila Tenani, Marcela Augusta de Souza Pinhel, Letícia Carolina Paraboli Assoni, Augusto Haniu Nakahara, Natalia Dos Santos Jábali, Octavio Pennella Fenelon Costa, Maria Eduarda Lopes Baitello, Sidney Pinheiro Júnior, Renato Ferreira Silva, Rita de Cássia Martins Alves da Silva, Dorotéia Rossi da Silva Souza
Abstract
Objective: ) in patients with cirrhosis with or without hepatocellular carcinoma (HCC), including demographic/clinical/biochemical profiles. Methods: = 158) with or without HCC, distributed into Group 1 (G1): cirrhosis and HCC; Group 2 (G2): isolated cirrhosis; and 225 individuals without hepatopathies (G3). Polymorphisms were analysed by real-time polymerase chain reaction. An alpha error of 5% was admitted. Results: = 0.0282). Conclusion: provides increased survival, suggesting a protective characteristic. Advanced age, alcoholism, DM, viral hepatitis and high levels of GGT, AFP and creatinine are also confirmed as predictors of HCC and cirrhosis, while smoking, alcoholism and DM for isolated cirrhosis only.