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Network pharmacology and in vivo studies reveal the pharmacological effects and molecular mechanisms of Celastrol against acute hepatic injury induced by LPS

Tianyuan Yang, Shuping Zhao, Ning Sun, Yuan Zhao, Hui Wang, Yuntong Zhang, Xiaoyu Hou, Yulin Tang, Xiang Gao, Honggang Fan

2023International Immunopharmacology11 citationsDOI

Topics & Concepts

Tripterygium wilfordiiProtein kinase BPI3K/AKT/mTOR pathwayPharmacologyKEGGIn vivoMAPK/ERK pathwayCelastrolOxidative stressApoptosisSignal transductionChemistryBiologyMedicineBiochemistryGene expressionPathologyGeneBiotechnologyTranscriptomeAlternative medicineNatural Compounds in Disease TreatmentDrug Transport and Resistance MechanismsNatural product bioactivities and synthesis
Network pharmacology and in vivo studies reveal the pharmacological effects and molecular mechanisms of Celastrol against acute hepatic injury induced by LPS | Litcius