Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center
Chunhui Zhou, Hao Zhao, Fan Yang, Luokai Huangfu, Chao Dong, Shuwei Wang, Jianning Zhang
Abstract
BACKGROUND AND PURPOSE: Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis. METHODS: Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Data on clinicopathological characteristics were analyzed and factors associated with patient survival were identified using a Cox regression model. RESULTS: loss conferred a survival advantage. CONCLUSIONS: Adult BSGs showed different molecular genetic characteristics, but also resembled supratentorial gliomas in their clinical features associated with oncological outcomes.