Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks
Natalie E. Dean, Pierre‐Stéphane Gsell, Ron Brookmeyer, Forrest W. Crawford, Christl A. Donnelly, Susan S. Ellenberg, Thomas R. Fleming, M. Elizabeth Halloran, Peter Horby, Thomas Jaki, Philip R. Krause, Ira M. Longini, Sabue Mulangu, Jean-Jacques Muyembe-Tamfum, Martha Nason, Peter G. Smith, Rui Wang, Ana María Henao-Restrepo, Victor De Gruttola
Abstract
As in the ongoing Covid-19 pandemic, global outbreaks of infectious illnesses often develop quickly and resolve in unpredictable ways. In this report, strategies to develop high-quality evidence to guide the development of new therapies are proposed.
Topics & Concepts
MedicineOutbreakDiseaseRandomized controlled trialClinical trialMEDLINEIntensive care medicineVirologyInternal medicinePolitical scienceLawViral Infections and Outbreaks ResearchDisaster Response and ManagementCOVID-19 and healthcare impacts